IDPfun2 is an international initiative focused on advancing our understanding of intrinsically disordered proteins (IDPs) and regions (IDRs), which have reshaped our view of protein function.

Unlike traditional proteins with rigid, well-defined structures, IDPs are highly dynamic, sampling a range of conformations that allow them to perform critical molecular functions. Despite their importance, studying IDPs has been challenging due to their inherent flexibility, which has limited our ability to fully characterize them.

Building on the success of the original IDPfun Consortium, IDPfun2 brings together seven leading European institutions and five top Argentinian partners, combining expertise in data management, machine learning, and structural biology. Together, these partners are working to push the boundaries of IDP characterization using state-of-the-art AI-based computational methods and novel data.

The project will focus on understanding IDPs’ molecular behavior across different biological and evolutionary contexts, with the aim of transforming our knowledge of their roles in cellular regulation and disease.

IDPfun2 will establish new standards and frameworks to better understand the complexity of IDPs and provide a collaborative training ground for the next generation of scientists. By expanding the knowledge of IDPs and their functional roles, the project seeks to contribute valuable insights to global protein databases, benefiting both the scientific community and biomedical applications with significant implications for human health and disease.