{"id":32,"date":"2024-07-18T15:34:49","date_gmt":"2024-07-18T15:34:49","guid":{"rendered":"https:\/\/idpfun.eu\/archive\/?page_id=32"},"modified":"2024-09-10T15:22:58","modified_gmt":"2024-09-10T13:22:58","slug":"research","status":"publish","type":"page","link":"https:\/\/idpfun.eu\/archive\/research\/","title":{"rendered":"Research"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\">Project aims<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:clamp(0.875rem, 0.875rem + ((1vw - 0.2rem) * 0.227), 1rem);\">Overall objective of IDPfun research is to address major current and future challenges in IDP field: to improve our understanding of IDP biological functions and translate this knowledge into major international databases for wider scientific community benefit. During the project lifetime we will solve a set of major problems in protein science and bioinformatics that are highly innovative:<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-3a88641f wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:20%\">\n<p class=\"wp-block-paragraph\"><strong>Scientific objectives<\/strong><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<ul class=\"wp-block-list\">\n<li>Creating novel ways to detect IDPs and their functions from sequence, structure and literature<\/li>\n\n\n\n<li>Classifying IDP function exhaustively in the context of evolution and sequence\/structure features<\/li>\n\n\n\n<li>Understanding and modeling the mechanisms driving IDP function through conformations and their transitions<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-3a88641f wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:20%\">\n<p class=\"wp-block-paragraph\"><strong>Technological objectives<\/strong><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<ul class=\"wp-block-list\">\n<li>Translate the knowledge of IDP function into major databases (e.g. UniProt)<\/li>\n\n\n\n<li>Define ontologies for IDP classification<\/li>\n\n\n\n<li>Develop common guidelines for reliable IDP annotation<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-3a88641f wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:20%\">\n<p class=\"wp-block-paragraph\"><strong>Societal objectives<\/strong><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<ul class=\"wp-block-list\">\n<li>Raise awareness for IDPs in life sciences at large<\/li>\n\n\n\n<li>Train researchers to use novel IDP resources<\/li>\n\n\n\n<li>Improve the impact of European science in Latin America and vice versa<\/li>\n\n\n\n<li>Promote scientific excellence and best practices<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Scientific focus<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">IDPfun project consists of five interlinked work packages, arranged in order to cover the ground from the current state of the art of IDP detection and classification, towards the definition of functional mechanisms and their translation towards wider scientific community by deploying gathered knowledge in public international databases, such as UniProt.<\/p>\n\n\n\n<div class=\"wp-block-query is-layout-flow wp-block-query-is-layout-flow\"><ul class=\"wp-block-post-template is-layout-grid wp-container-core-post-template-is-layout-51876875 wp-block-post-template-is-layout-grid\"><li class=\"wp-block-post post-140 research type-research status-publish hentry\">\n\n<div class=\"wp-block-group has-border-color has-base-3-background-color has-background tw-stretched-link is-layout-flow wp-container-core-group-is-layout-b4d04ffe wp-block-group-is-layout-flow\" style=\"border-color:#00000030;border-width:1px;border-radius:5px;min-height:275px\">\n<div class=\"wp-block-group has-base-2-background-color has-background tw-stretched-link is-content-justification-space-between is-layout-flex wp-container-core-group-is-layout-fa82c882 wp-block-group-is-layout-flex\" style=\"border-bottom-color:#f3ca94;border-bottom-width:1px;padding-top:var(--wp--preset--spacing--10);padding-right:var(--wp--preset--spacing--10);padding-bottom:var(--wp--preset--spacing--10);padding-left:var(--wp--preset--spacing--10)\"><h5 class=\"is-acf-field is-text-field wp-elements-ac6ed8579847a39ce412791ba7c4206a wp-block-mfb-meta-field-block has-text-color has-contrast-3-color\"><span class=\"value\">IDP Function detection<\/span><\/h5>\n\n<h5 class=\"wp-block-post-title\"><a href=\"https:\/\/idpfun.eu\/archive\/research\/wp1\/\" target=\"_self\" >WP1<\/a><\/h5><\/div>\n\n\n<div style=\"padding-right:var(--wp--preset--spacing--10);padding-left:var(--wp--preset--spacing--10);padding-top:var(--wp--preset--spacing--10);padding-bottom:var(--wp--preset--spacing--10);\" class=\"wp-block-post-excerpt\"><p class=\"wp-block-post-excerpt__excerpt\">WP1 will lay the foundation for detecting IDPs in different contexts. It will provide a complete set of tools for IDR detection from difference sources, including protein sequences, protein structures and literature. Starting from existing<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/idpfun.eu\/archive\/research\/wp1\/\">More  \u2192<\/a><\/p><\/div><\/div>\n\n<\/li><li class=\"wp-block-post post-142 research type-research status-publish hentry\">\n\n<div class=\"wp-block-group has-border-color has-base-3-background-color has-background tw-stretched-link is-layout-flow wp-container-core-group-is-layout-b4d04ffe wp-block-group-is-layout-flow\" style=\"border-color:#00000030;border-width:1px;border-radius:5px;min-height:275px\">\n<div class=\"wp-block-group has-base-2-background-color has-background tw-stretched-link is-content-justification-space-between is-layout-flex wp-container-core-group-is-layout-fa82c882 wp-block-group-is-layout-flex\" style=\"border-bottom-color:#f3ca94;border-bottom-width:1px;padding-top:var(--wp--preset--spacing--10);padding-right:var(--wp--preset--spacing--10);padding-bottom:var(--wp--preset--spacing--10);padding-left:var(--wp--preset--spacing--10)\"><h5 class=\"is-acf-field is-text-field wp-elements-ac6ed8579847a39ce412791ba7c4206a wp-block-mfb-meta-field-block has-text-color has-contrast-3-color\"><span class=\"value\">IDP Function classification<\/span><\/h5>\n\n<h5 class=\"wp-block-post-title\"><a href=\"https:\/\/idpfun.eu\/archive\/research\/wp2\/\" target=\"_self\" >WP2<\/a><\/h5><\/div>\n\n\n<div style=\"padding-right:var(--wp--preset--spacing--10);padding-left:var(--wp--preset--spacing--10);padding-top:var(--wp--preset--spacing--10);padding-bottom:var(--wp--preset--spacing--10);\" class=\"wp-block-post-excerpt\"><p class=\"wp-block-post-excerpt__excerpt\">WP2 will try to establish the best possible classification of different IDP phenomena and solve detection issues. IDPs are associated to many different protein functions that are very well described in the literature but not&hellip;<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/idpfun.eu\/archive\/research\/wp2\/\">More  \u2192<\/a><\/p><\/div><\/div>\n\n<\/li><li class=\"wp-block-post post-144 research type-research status-publish hentry\">\n\n<div class=\"wp-block-group has-border-color has-base-3-background-color has-background tw-stretched-link is-layout-flow wp-container-core-group-is-layout-b4d04ffe wp-block-group-is-layout-flow\" style=\"border-color:#00000030;border-width:1px;border-radius:5px;min-height:275px\">\n<div class=\"wp-block-group has-base-2-background-color has-background tw-stretched-link is-content-justification-space-between is-layout-flex wp-container-core-group-is-layout-fa82c882 wp-block-group-is-layout-flex\" style=\"border-bottom-color:#f3ca94;border-bottom-width:1px;padding-top:var(--wp--preset--spacing--10);padding-right:var(--wp--preset--spacing--10);padding-bottom:var(--wp--preset--spacing--10);padding-left:var(--wp--preset--spacing--10)\"><h5 class=\"is-acf-field is-text-field wp-elements-ac6ed8579847a39ce412791ba7c4206a wp-block-mfb-meta-field-block has-text-color has-contrast-3-color\"><span class=\"value\">IDP Function mechanisms<\/span><\/h5>\n\n<h5 class=\"wp-block-post-title\"><a href=\"https:\/\/idpfun.eu\/archive\/research\/wp3\/\" target=\"_self\" >WP3<\/a><\/h5><\/div>\n\n\n<div style=\"padding-right:var(--wp--preset--spacing--10);padding-left:var(--wp--preset--spacing--10);padding-top:var(--wp--preset--spacing--10);padding-bottom:var(--wp--preset--spacing--10);\" class=\"wp-block-post-excerpt\"><p class=\"wp-block-post-excerpt__excerpt\">WP3 will exploit methods and analyses from previous work packages trying to provide a full understanding of mechanisms through which IDPs exert biological functions. IDP behavior will be addressed in a context-dependent way. It will&hellip;<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/idpfun.eu\/archive\/research\/wp3\/\">More  \u2192<\/a><\/p><\/div><\/div>\n\n<\/li><li class=\"wp-block-post post-146 research type-research status-publish hentry\">\n\n<div class=\"wp-block-group has-border-color has-base-3-background-color has-background tw-stretched-link is-layout-flow wp-container-core-group-is-layout-b4d04ffe wp-block-group-is-layout-flow\" style=\"border-color:#00000030;border-width:1px;border-radius:5px;min-height:275px\">\n<div class=\"wp-block-group has-base-2-background-color has-background tw-stretched-link is-content-justification-space-between is-layout-flex wp-container-core-group-is-layout-fa82c882 wp-block-group-is-layout-flex\" style=\"border-bottom-color:#f3ca94;border-bottom-width:1px;padding-top:var(--wp--preset--spacing--10);padding-right:var(--wp--preset--spacing--10);padding-bottom:var(--wp--preset--spacing--10);padding-left:var(--wp--preset--spacing--10)\"><h5 class=\"is-acf-field is-text-field wp-elements-ac6ed8579847a39ce412791ba7c4206a wp-block-mfb-meta-field-block has-text-color has-contrast-3-color\"><span class=\"value\">IDP Translation &amp; Deployment<\/span><\/h5>\n\n<h5 class=\"wp-block-post-title\"><a href=\"https:\/\/idpfun.eu\/archive\/research\/wp4\/\" target=\"_self\" >WP4<\/a><\/h5><\/div>\n\n\n<div style=\"padding-right:var(--wp--preset--spacing--10);padding-left:var(--wp--preset--spacing--10);padding-top:var(--wp--preset--spacing--10);padding-bottom:var(--wp--preset--spacing--10);\" class=\"wp-block-post-excerpt\"><p class=\"wp-block-post-excerpt__excerpt\">WP4 will translate and concentrate all the generated knowledge of previous WPs into core data resources. Tasks will provide guidelines for the community annotation of IDP from literature, as well as best practices to design&hellip;<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/idpfun.eu\/archive\/research\/wp4\/\">More  \u2192<\/a><\/p><\/div><\/div>\n\n<\/li><li class=\"wp-block-post post-148 research type-research status-publish hentry\">\n\n<div class=\"wp-block-group has-border-color has-base-3-background-color has-background tw-stretched-link is-layout-flow wp-container-core-group-is-layout-b4d04ffe wp-block-group-is-layout-flow\" style=\"border-color:#00000030;border-width:1px;border-radius:5px;min-height:275px\">\n<div class=\"wp-block-group has-base-2-background-color has-background tw-stretched-link is-content-justification-space-between is-layout-flex wp-container-core-group-is-layout-fa82c882 wp-block-group-is-layout-flex\" style=\"border-bottom-color:#f3ca94;border-bottom-width:1px;padding-top:var(--wp--preset--spacing--10);padding-right:var(--wp--preset--spacing--10);padding-bottom:var(--wp--preset--spacing--10);padding-left:var(--wp--preset--spacing--10)\"><h5 class=\"is-acf-field is-text-field wp-elements-ac6ed8579847a39ce412791ba7c4206a wp-block-mfb-meta-field-block has-text-color has-contrast-3-color\"><span class=\"value\">Training, Management &amp; Dissemination<\/span><\/h5>\n\n<h5 class=\"wp-block-post-title\"><a href=\"https:\/\/idpfun.eu\/archive\/research\/wp5\/\" target=\"_self\" >WP5<\/a><\/h5><\/div>\n\n\n<div style=\"padding-right:var(--wp--preset--spacing--10);padding-left:var(--wp--preset--spacing--10);padding-top:var(--wp--preset--spacing--10);padding-bottom:var(--wp--preset--spacing--10);\" class=\"wp-block-post-excerpt\"><p class=\"wp-block-post-excerpt__excerpt\">WP5 will provide the dissemination-training-management layer covering the entire project. Meetings and visits are intended to recapitulate project advances and to concentrate resources providing network-wide training. Dissemination training schools will disseminate project objectives and results&hellip;<\/p><p class=\"wp-block-post-excerpt__more-text\"><a class=\"wp-block-post-excerpt__more-link\" href=\"https:\/\/idpfun.eu\/archive\/research\/wp5\/\">More  \u2192<\/a><\/p><\/div><\/div>\n\n<\/li><\/ul><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Project aims Overall objective of IDPfun research is to address major current and future challenges in IDP field: to improve our understanding of IDP biological functions and translate this knowledge into major international databases for wider scientific community benefit. During the project lifetime we will solve a set of major problems in protein science and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"wp-custom-template-pages","meta":{"_acf_changed":false,"_crdt_document":"","_themeisle_gutenberg_block_has_review":false,"footnotes":""},"class_list":["post-32","page","type-page","status-publish","hentry"],"acf":[],"mb":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Research - IDPfun<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/idpfun.eu\/archive\/research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research - IDPfun\" \/>\n<meta property=\"og:description\" content=\"Project aims Overall objective of IDPfun research is to address major current and future challenges in IDP field: to improve our understanding of IDP biological functions and translate this knowledge into major international databases for wider scientific community benefit. 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