Project aims
Overall, IDPfun2 aims to advance our understanding of IDRs, their properties, functions, and implications in various biological processes and diseases.
The project’s objectives encompass a broad range of research activities, including data generation, software development, functional characterization, and disease-related investigations. On a larger scale the project includes societal objectives like raising awareness of IDRs in the life sciences community and providing training to researchers on the utilisation of novel IDP resources:
Scientific objectives
- Creating novel ways to detect IDPs and their functions from sequence, structure and literature
- Classifying IDP function exhaustively in the context of evolution and sequence/structure features
- Understanding and modeling the mechanisms driving IDP function through conformations and their transitions
Technological objectives
- Translate the knowledge of IDP function into major databases (e.g. UniProt)
- Define ontologies for IDP classification
- Develop common guidelines for reliable IDP annotation
Societal objectives
- Raise awareness for IDPs in life sciences at large
- Train researchers to use novel IDP resources
- Improve the impact of European science in Latin America and vice versa
- Promote scientific excellence and best practices
Scientific focus
IDPfun project consists of five interlinked work packages, arranged in order to cover the ground from the current state of the art of IDP detection and classification, towards the definition of functional mechanisms and their translation towards wider scientific community by deploying gathered knowledge in public international databases, such as UniProt.