H2020 MSCA-RISE project

Project aims

Overall objective of IDPfun research is to address major current and future challenges in IDP field: to improve our understanding of IDP biological functions and translate this knowledge into major international databases for wider scientific community benefit. During the project lifetime we will solve a set of major problems in protein science and bioinformatics that are highly innovative:

Scientific objectives

  • Creating novel ways to detect IDPs and their functions from sequence, structure and literature
  • Classifying IDP function exhaustively in the context of evolution and sequence/structure features
  • Understanding and modeling the mechanisms driving IDP function through conformations and their transitions

Technological objectives

  • Translate the knowledge of IDP function into major databases (e.g. UniProt)
  • Define ontologies for IDP classification
  • Develop common guidelines for reliable IDP annotation

Societal objectives

  • Raise awareness for IDPs in life sciences at large
  • Train researchers to use novel IDP resources
  • Improve the impact of European science in Latin America and vice versa
  • Promote scientific excellence and best practices

Scientific focus

IDPfun project consists of five interlinked work packages, arranged in order to cover the ground from the current state of the art of IDP detection and classification, towards the definition of functional mechanisms and their translation towards wider scientific community by deploying gathered knowledge in public international databases, such as UniProt.

  • IDP Function detection
    WP1

    WP1 will lay the foundation for detecting IDPs in different contexts. It will provide a complete set of tools for IDR detection from difference sources, including protein sequences, protein structures and literature. Starting from existing

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  • IDP Function classification
    WP2

    WP2 will try to establish the best possible classification of different IDP phenomena and solve detection issues. IDPs are associated to many different protein functions that are very well described in the literature but not…

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  • IDP Function mechanisms
    WP3

    WP3 will exploit methods and analyses from previous work packages trying to provide a full understanding of mechanisms through which IDPs exert biological functions. IDP behavior will be addressed in a context-dependent way. It will…

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  • IDP Translation & Deployment
    WP4

    WP4 will translate and concentrate all the generated knowledge of previous WPs into core data resources. Tasks will provide guidelines for the community annotation of IDP from literature, as well as best practices to design…

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  • Training, Management & Dissemination
    WP5

    WP5 will provide the dissemination-training-management layer covering the entire project. Meetings and visits are intended to recapitulate project advances and to concentrate resources providing network-wide training. Dissemination training schools will disseminate project objectives and results…

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